The functional mechanism of simvastatin in experimental osteoporosis
| Autor: | Yuan Wang, Min Hu, Haiying Wu, Ming Xu, Hongbin Zhao, Lanjie Xue, Lifen Dai, Dekai Yuan, Zhiqiang Shen |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Simvastatin Endocrinology Diabetes and Metabolism Osteoporosis Pharmacology Bioinformatics Metabolic bone disease 03 medical and health sciences Endocrinology Animal model Bone Density Osteoporosis treatment polycyclic compounds medicine Animals Orthopedics and Sports Medicine cardiovascular diseases Cell Proliferation Curative effect Osteoblasts Mechanism (biology) business.industry nutritional and metabolic diseases Cell Differentiation General Medicine medicine.disease Disease Models Animal 030104 developmental biology lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | Journal of Bone and Mineral Metabolism. 34:23-32 |
| ISSN: | 1435-5604 0914-8779 |
| DOI: | 10.1007/s00774-014-0638-y |
| Popis: | Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use of animal models, the treatment effectiveness of simvastatin on experimental osteoporosis was investigated and the functional mechanism was preliminarily explored. The results show that simvastatin significantly increased the mechanical parameters such as maximum load, stiffness, and energy-absorbing capacity, and improved the microarchitecture. They indicated that the antiosteoporosis activity of simvastatin may be due to the promotion of proliferation and differentiation of osteoblasts. Simvastatin was effective in treating experimental osteoporosis. This study provides necessary experimental evidence for the clinical application of simvastatin in osteoporosis treatment. |
| Databáze: | OpenAIRE |
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