Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease
| Autor: | Marion A, van Dijken Pj, James L.M. Ferrara, Francisco J. Guillen, Steven J. Burakoff, George F. Murphy |
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| Rok vydání: | 1989 |
| Předmět: |
Cytotoxicity
Immunologic Transplantation Immunity Cellular Effector Lymphocyte Graft vs Host Disease chemical and pharmacologic phenomena Mice Inbred Strains T lymphocyte Biology Peripheral blood mononuclear cell Tissue Donors Natural killer cell Killer Cells Natural CTL Mice medicine.anatomical_structure Immunology medicine Animals Bone marrow Spleen Bone Marrow Transplantation |
| Zdroj: | Transplantation. 47(1) |
| ISSN: | 0041-1337 |
| Popis: | We have studied the phenotype of mononuclear cells infiltrating target organs of mice with acute graft-versus-host disease after bone marrow transplantation from H-2-identical donors. Infiltrating mononuclear cells with characteristics of large granular lymphocytes (LGL) were frequently found in close association with dead or dying epithelial cells in the skin, liver, and colon. The phenotype of these putative effector cells was Thy-1+, ASGM1+, Mac-1+, Lyt-1-, Lyt-2-, Ia-, which is characteristic of LGL. Differences in the Thy-1 allele between donor and host were used to demonstrate that these cells were of donor origin. Analysis of cytolytic function in GVHD splenocytes indicated high natural killer activity and low cytolytic T lymphocyte (CTL) activity. These findings suggest that an important effector cell in systemic acute graft-versus-host disease is a large granular lymphocyte of donor origin. |
| Databáze: | OpenAIRE |
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