Histologic factors associated with nintedanib efficacy in patients with idiopathic pulmonary fibrosis

Autor: Yasuhiro Kondoh, Kishio Kuroda, Masahiro Aoshima, Kazuhiro Tabata, Junya Fukuoka, Masahiro Nemoto, Andrey Bychkov, Yoshiaki Zaizen, Kensuke Kataoka, Takeshi Johkoh, Hiromitsu Sumikawa
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Indoles
Pulmonary Fibrosis
Biopsy
Cancer Treatment
Gastroenterology
Biochemistry
Diagnostic Radiology
chemistry.chemical_compound
Idiopathic pulmonary fibrosis
Interquartile range
Pulmonary fibrosis
Medicine and Health Sciences
Tomography
Lung
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
Pulmonary Imaging
Survival Rate
medicine.anatomical_structure
Oncology
Medicine
Nintedanib
Female
Anatomy
Research Article
medicine.medical_specialty
Histology
Imaging Techniques
Science
Neuroimaging
Surgical and Invasive Medical Procedures
Research and Analysis Methods
Disease-Free Survival
Diagnostic Medicine
Internal medicine
medicine
Humans
Aged
Retrospective Studies
business.industry
Biology and Life Sciences
medicine.disease
Fibrosis
Idiopathic Pulmonary Fibrosis
Computed Axial Tomography
Pneumonia
chemistry
Specimen Preparation and Treatment
Histopathology
business
Biomarkers
Neuroscience
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0245147 (2021)
ISSN: 1932-6203
Popis: Background Histopathologic factors predictive of nintedanib efficacy in idiopathic pulmonary fibrosis have not been studied. We aimed to describe the characteristics, focusing on histopathology, of idiopathic pulmonary fibrosis patients who did and did not respond to nintedanib. Methods This study retrospectively examined the clinicoradiopathologic features of 40 consecutive patients with surgical lung biopsy-confirmed idiopathic pulmonary fibrosis treated with nintedanib. Additionally, we compared the histopathologic scoring of 21 microscopic features between patients with functional or radiological progression and those with non-progression during 12 months of treatment. Results The histopathologic evaluation showed edematous changes in the interlobular septum as the only histologic finding observed more frequently in patients with both functional and radiological progression than in those without (58% vs. 14%, P = 0.007 and 50% vs. 0%, P = 0.003, respectively). Regarding per-year change, patients with edematous changes in the interlobular septum showed greater progression in median changes in spared area (-12%, interquartile range: [-25%-5%], vs. -3% [-7%-0%], P = 0.004) and reticular shadow (7% [3%-13%], vs. 0% [0%-5%], P = 0.041) on computed tomography. Functional and radiological progression-free survival were shorter in patients with edematous changes in the interlobular septum than in those without (6.6 months, 95% confidence interval: [5.9-25.3], vs. event
PLOS ONE, 16, art.no.e0245147; 2021
Databáze: OpenAIRE
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