Histologic factors associated with nintedanib efficacy in patients with idiopathic pulmonary fibrosis
Autor: | Yasuhiro Kondoh, Kishio Kuroda, Masahiro Aoshima, Kazuhiro Tabata, Junya Fukuoka, Masahiro Nemoto, Andrey Bychkov, Yoshiaki Zaizen, Kensuke Kataoka, Takeshi Johkoh, Hiromitsu Sumikawa |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Male
Indoles Pulmonary Fibrosis Biopsy Cancer Treatment Gastroenterology Biochemistry Diagnostic Radiology chemistry.chemical_compound Idiopathic pulmonary fibrosis Interquartile range Pulmonary fibrosis Medicine and Health Sciences Tomography Lung Multidisciplinary medicine.diagnostic_test Radiology and Imaging Middle Aged Pulmonary Imaging Survival Rate medicine.anatomical_structure Oncology Medicine Nintedanib Female Anatomy Research Article medicine.medical_specialty Histology Imaging Techniques Science Neuroimaging Surgical and Invasive Medical Procedures Research and Analysis Methods Disease-Free Survival Diagnostic Medicine Internal medicine medicine Humans Aged Retrospective Studies business.industry Biology and Life Sciences medicine.disease Fibrosis Idiopathic Pulmonary Fibrosis Computed Axial Tomography Pneumonia chemistry Specimen Preparation and Treatment Histopathology business Biomarkers Neuroscience Developmental Biology |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 1, p e0245147 (2021) |
ISSN: | 1932-6203 |
Popis: | Background Histopathologic factors predictive of nintedanib efficacy in idiopathic pulmonary fibrosis have not been studied. We aimed to describe the characteristics, focusing on histopathology, of idiopathic pulmonary fibrosis patients who did and did not respond to nintedanib. Methods This study retrospectively examined the clinicoradiopathologic features of 40 consecutive patients with surgical lung biopsy-confirmed idiopathic pulmonary fibrosis treated with nintedanib. Additionally, we compared the histopathologic scoring of 21 microscopic features between patients with functional or radiological progression and those with non-progression during 12 months of treatment. Results The histopathologic evaluation showed edematous changes in the interlobular septum as the only histologic finding observed more frequently in patients with both functional and radiological progression than in those without (58% vs. 14%, P = 0.007 and 50% vs. 0%, P = 0.003, respectively). Regarding per-year change, patients with edematous changes in the interlobular septum showed greater progression in median changes in spared area (-12%, interquartile range: [-25%-5%], vs. -3% [-7%-0%], P = 0.004) and reticular shadow (7% [3%-13%], vs. 0% [0%-5%], P = 0.041) on computed tomography. Functional and radiological progression-free survival were shorter in patients with edematous changes in the interlobular septum than in those without (6.6 months, 95% confidence interval: [5.9-25.3], vs. event PLOS ONE, 16, art.no.e0245147; 2021 |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |