Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis

Autor: N. Venisse, Jiad N. Mcheik, Philippe Vasseur, Christine Silvain, Laure Favot, Jean-Claude Lecron, Mathilde Pohin, Jean-François Jégou, Franck Morel
Přispěvatelé: Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers)
Rok vydání: 2018
Předmět:
Liver Cirrhosis
Male
0301 basic medicine
Pathology
medicine.medical_specialty
Interferon Inducers
education
Imiquimod
macromolecular substances
Dermatology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Psoriasis
medicine
Animals
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Psoriasiform Dermatitis
Sirius Red
ComputingMilieux_MISCELLANEOUS
health care economics and organizations
Hepatitis
Liver injury
integumentary system
business.industry
medicine.disease
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biomolecules [q-bio.BM]
3. Good health
Mice
Inbred C57BL
Disease Models
Animal
030104 developmental biology
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
chemistry
Immunology
Hepatic stellate cell
Drug Eruptions
Chemical and Drug Induced Liver Injury
business
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
medicine.drug
Zdroj: British Journal of Dermatology
British Journal of Dermatology, Wiley, 2018, 179, pp.101-109. ⟨10.1111/bjd.16137⟩
British Journal of Dermatology, Wiley, In press, ⟨10.1111/bjd.16137⟩
ISSN: 0007-0963
1365-2133
Popis: SummaryBackground Psoriasis associates several extra-cutaneous manifestations. Little is known about hepatic parameters specifically associated with psoriasis. Objective To study whether psoriasiform dermatitis is associated with liver injury. Methods We studied liver parameters of inflammation and fibrosis in a murine model of psoriasiform dermatitis induced by topical application of imiquimod for nine weeks. Results Topical treatment with imiquimod induced a form of psoriasiform dermatitis reminiscent of the human disorder, characterized by thickened and scaly skin, psoriasiform epidermal hyperplasia, altered keratinocyte differentiation, and cutaneous overexpression of interleukin-17A. Mice with dermatitis displayed hepatitis, as shown by elevation of plasma transaminase levels, as well as portal and periportal hepatitis characterized by T lymphocyte (CD3e+) and polymorphonuclear cell (Gr1+) infiltrates. The hepatitis progressed toward liver fibrogenesis, as shown by excessive Sirius red staining, consistent with the expression of alpha-smooth muscle actin by hepatic stellate cells. Conclusions These results indicate that liver inflammation and fibrosis is associated with experimental psoriasiform dermatitis. Our results suggest that psoriatic inflammation may be associated with specific liver injury. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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