| Autor: |
Bolni Marius Nagalo, Yumei Zhou, Emilien J. Loeuillard, Chelsae Dumbauld, Oumar Barro, Natalie M. Elliott, Alexander T. Baker, Mansi Arora, James M. Bogenberger, Nathalie Meurice, Joachim Petit, Pedro Luiz Serrano Uson, Faaiq Aslam, Elizabeth Raupach, Musa Gabere, Alexei Basnakian, Camila C. Simoes, Martin J. Cannon, Steven R. Post, Kenneth Buetow, Jean Christopher Chamcheu, Michael T. Barrett, Dan G. Duda, Bertram Jacobs, Richard Vile, Michael A. Barry, Lewis R. Roberts, Sumera Ilyas, Mitesh J. Borad |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Hepatology. 77:1943-1957 |
| ISSN: |
0270-9139 |
| DOI: |
10.1002/hep.32769 |
| Popis: |
Morreton virus (MORV) is an oncolytic Vesiculovirus, genetically distinct from vesicular stomatitis virus (VSV).To report that MORV induced potent cytopathic effects (CPEs) in cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) in vitro models.In preliminary safety analyses, high intranasal doses (up to 10Our findings indicate that wild-type MORV is safe and can induce potent tumor regression via immune-mediated and immune-independent mechanisms in HCC and CCA animal models without dose limiting adverse events. These data warrant further development and clinical translation of MORV as an oncolytic virotherapy platform. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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