Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis

Autor:	Ömer, Zaim, Oğuzhan, Doğanlar, Zeynep, Banu Doğanlar, Hafize, Özcan, Mohamed M, Zreigh, Kardelen, Kurtdere
Rok vydání:	2022
Předmět:	STAT3 Transcription Factor Interleukin-6 Cell Line Tumor Organic Chemistry Drug Discovery Humans Apoptosis Janus Kinase 2 Glioblastoma Hypoxia Molecular Biology Biochemistry Piperazines
Zdroj:	Bioorganic Chemistry. 129:106209
ISSN:	0045-2068
DOI:	10.1016/j.bioorg.2022.106209
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f566f5dfef72b93b1ac70a65fc1e7e https://doi.org/10.1016/j.bioorg.2022.106209 Zobrazit plný text záznamu Full Text from ScienceDirect