New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367

Autor:	Hideo Hirai, Ayumu Sugiura, Nakao Kojima, Yutaka Sugie, Nobuji Yqshikawa, Joan Duignan, Yukio Shiomi, Joyce A. Sutcliffe, Yoon-Jeong Kim, Liang Hsiung Huang, Akemi Sugiura, Yasuhiro Kojima, Lori Brennan, Yumiko Suzuki, Hiroko Kachi-Tonai
Rok vydání:	2002
Předmět:	Optical Rotation Spectrophotometry Infrared medicine.drug_class Antibiotics Fungus Microbial Sensitivity Tests medicine.disease_cause Gram-Positive Bacteria Gas Chromatography-Mass Spectrometry Microbiology Moraxella catarrhalis Minimum inhibitory concentration Lactones Drug Resistance Multiple Bacterial Drug Discovery Gram-Negative Bacteria medicine Humans Pyrroles Escherichia coli Nuclear Magnetic Resonance Biomolecular Antibacterial agent Pharmacology biology Fungi Biological activity Stereoisomerism biology.organism_classification Anti-Bacterial Agents Molecular Weight Biochemistry Fermentation Spectrophotometry Ultraviolet HeLa Cells
Zdroj:	The Journal of antibiotics. 54(11)
ISSN:	0021-8820
Popis:	Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f49b8411319ca62acd39bf55fa1ad2 https://pubmed.ncbi.nlm.nih.gov/11827034 Zobrazit plný text záznamu