Differences in the microbial profiles of early stage endometrial cancers between Black and White women

Autor: Gabrielle M, Hawkins, Wesley C, Burkett, Amber N, McCoy, Hazel B, Nichols, Andrew F, Olshan, Russell, Broaddus, Jason D, Merker, Bernard, Weissman, Wendy R, Brewster, Jeffrey, Roach, Temitope O, Keku, Victoria, Bae-Jump
Rok vydání: 2022
Předmět:
Zdroj: Gynecol Oncol
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2022.02.021
Popis: OBJECTIVE: Black women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesize that another biological factor driving this racial disparity could be the EC microbiome. METHODS: Banked tumor specimens of postmenopausal, Black and White women undergoing hysterectomy for early stage endometrioid EC were identified. The microbiota of the tumors were characterized by bacterial 16S rRNA sequencing. The microbial component of endometrioid ECs in The Cancer Genome Atlas (TCGA) database were assessed for comparison. RESULTS: 95 early stage ECs were evaluated: 23 Black (24%) and 72 White (76%). Microbial diversity was increased (p
Databáze: OpenAIRE
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