A heat-stable microparticle platform for oral micronutrient delivery
| Autor: | Ana Sofia Guerra, Michael B. Zimmermann, Lowell L. Wood, Jia Zhuang, Tyler Graf, Shelley B. Weinstock, Stephany Y. Tzeng, Aranda R. Duan, Christopher B. Sears, Xiao Le, Adam M. Behrens, Philip A. Welkhoff, Joe Collins, Wen Tang, Simone Buerkli, Diego Moretti, Thanh D. Nguyen, Sarah Acolatse, Xueguang Lu, Lisa E. Freed, Xian Xu, Ana Jaklenec, Robert Langer, Sviatlana Rose, Kevin J. McHugh, Aaron C. Anselmo, Evan M. Rosenberg, Boris Nikolic, James L. Sugarman, Yingying Zeng, James D. Oxley |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Micronutrient deficiency Hot Temperature Ultraviolet Rays Iron Administration Oral Biological Availability 02 engineering and technology Intestinal absorption 03 medical and health sciences Mice Animals Humans Food science Micronutrients Microparticle Hyaluronic Acid Vitamin A 030109 nutrition & dietetics Chemistry Food fortification Natural polymers Water Biological Transport General Medicine 021001 nanoscience & nanotechnology Micronutrient Microspheres Bioavailability Intestines Drug Liberation Intestinal Absorption Delayed-Action Preparations Methacrylates Female 0210 nano-technology Oxidation-Reduction Niacin |
| Zdroj: | Joseph Collins |
| DOI: | 10.17615/zx5e-sv36 |
| Popis: | Micronutrient deficiencies affect up to 2 billion people and are the leading cause of cognitive and physical disorders in the developing world. Food fortification is effective in treating micronutrient deficiencies; however, its global implementation has been limited by technical challenges in maintaining micronutrient stability during cooking and storage. We hypothesized that polymer-based encapsulation could address this and facilitate micronutrient absorption. We identified poly(butylmethacrylate-co-(2-dimethylaminoethyl)methacrylate-co-methylmethacrylate) (1:2:1) (BMC) as a material with proven safety, offering stability in boiling water, rapid dissolution in gastric acid, and the ability to encapsulate distinct micronutrients. We encapsulated 11 micronutrients (iron; iodine; zinc; and vitamins A, B2, niacin, biotin, folic acid, B12, C, and D) and co-encapsulated up to 4 micronutrients. Encapsulation improved micronutrient stability against heat, light, moisture, and oxidation. Rodent studies confirmed rapid micronutrient release in the stomach and intestinal absorption. Bioavailability of iron from microparticles, compared to free iron, was lower in an initial human study. An organotypic human intestinal model revealed that increased iron loading and decreased polymer content would improve absorption. Using process development approaches capable of kilogram-scale synthesis, we increased iron loading more than 30-fold. Scaled batches tested in a follow-up human study exhibited up to 89% relative iron bioavailability compared to free iron. Collectively, these studies describe a broad approach for clinical translation of a heat-stable ingestible micronutrient delivery platform with the potential to improve micronutrient deficiency in the developing world. These approaches could potentially be applied toward clinical translation of other materials, such as natural polymers, for encapsulation and oral delivery of micronutrients. |
| Databáze: | OpenAIRE |
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