Central Nervous System Manifestations of Systemic Lupus Erythematosus
| Autor: | Sarah L. Patterson, Cristina Lanata, Kashif Jafri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
030203 arthritis & rheumatology
business.industry medicine.medical_treatment Lupus Vasculitis Central Nervous System Central nervous system Symptomatic treatment Immunosuppression Pathogenesis 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid medicine.anatomical_structure Rheumatology Neuroimaging Immunology Etiology medicine Humans business 030217 neurology & neurosurgery Anti-SSA/Ro autoantibodies |
| Zdroj: | Rheumatic Disease Clinics of North America. 43:531-545 |
| ISSN: | 0889-857X |
| DOI: | 10.1016/j.rdc.2017.06.003 |
| Popis: | Neuropsychiatric systemic lupus erythematosus (NPSLE) encompasses a variety of phenomena. Manifestations are focal or diffuse, and correlate with disease mechanisms. Recent understanding of the contribution of blood-brain barrier dysfunction to the passage of circulating antineuronal antibodies into the brain parenchyma has shed light on pathogenesis. Correct attribution of neuropsychiatric manifestations to SLE remains a challenge, but validated attribution models will help. Diagnosis relies on characteristic clinical manifestations, SLE disease activity, antibody measurements, cerebrospinal fluid findings, specific neuroimaging findings, and exclusion of alternative etiologies. Current treatment encompasses the identification and management of the inciting event, symptomatic treatment, and anticoagulation or immunosuppression. |
| Databáze: | OpenAIRE |
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