A case of acute lymphoblastic leukemia and throtrast-accumulation
| Autor: | Hannes Hanak, Ferdinand Ruzicka, Hadwiga Nowotny, Marie Antoinette Gobets, Alois Stacher |
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| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Lymphoblastic Leukemia Disease chemistry.chemical_compound hemic and lymphatic diseases Internal medicine Intensive therapy Humans Medicine Thorotrast Cerebral Hemorrhage Chromosome Aberrations Leukemia Radiation-Induced Hematology business.industry Public health Bone Marrow Examination General Medicine Middle Aged medicine.disease Leukemia Lymphoid Leukemia Liver chemistry Karyotyping Thorium Dioxide Lymph Nodes business Spleen |
| Zdroj: | Blut Zeitschrift für die Gesamte Blutforschung. 31:5-10 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf01635435 |
| Popis: | A case of acute lymphoblastic leukemia (ALL), in a 50 years old patient, 26 years after thorotrast injection, is reported. In spite of intensive therapy, he died 2 years after diagnosis of disease. The cytogenetic showed the usual thorotrast radiation-induced abnormalities, although to a greater extent than reported in leterature. Furthermore a hypodiploidy was present, which was connected with ALL. In addition the patient exhibited the interesting phenomenon of giant satellites on one of his D14-chromosomes. This abnormally was found also in his mother and son. The question arises, how far the inherited cytogenetic pattern and the thorotrast radiation each contributed to the development of ALL. |
| Databáze: | OpenAIRE |
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