Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants
| Autor: | Bente Ulvestad, Magny S. Thomassen, Berit Bakke, Ingebjørg Seljeflot, Dag G. Ellingsen, Yngvar Thomassen |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent P-selectin CD40 Ligand 030204 cardiovascular system & hematology Systemic inflammation Endothelial activation 03 medical and health sciences 0302 clinical medicine Occupational Exposure Internal medicine medicine Humans Platelet Platelet activation Vehicle Emissions chemistry.chemical_classification Norway Tumor Necrosis Factor-alpha business.industry Monocyte Construction Industry Fatty Acids Public Health Environmental and Occupational Health Fatty acid Thrombosis Quartz Middle Aged Intercellular Adhesion Molecule-1 Platelet Activation medicine.disease 030210 environmental & occupational health Carbon P-Selectin Endocrinology medicine.anatomical_structure chemistry Immunology Particulate Matter medicine.symptom business Biomarkers |
| Zdroj: | International Archives of Occupational and Environmental Health. 90:309-317 |
| ISSN: | 1432-1246 0340-0131 |
| DOI: | 10.1007/s00420-017-1199-x |
| Popis: | The aims were to study biomarkers of systemic inflammation, platelet/endothelial activation and thrombosis in tunnel construction workers (TCW). Biomarkers and blood fatty acids were measured in blood of 90 TCW and 50 referents before (baseline) and towards the end (follow-up) of a 12 days work period. They had been absent from work for 9 days at baseline. Air samples were collected by personal sampling. Personal thoracic air samples showed geometric mean (GM) particulate matter and α-quartz concentrations of 604 and 74 µg/m3, respectively. The arithmetic mean (AM) concentration of elemental carbon was 51 µg/m3. The GM (and 95% confidence interval) concentration of the pro-inflammatory cytokine TNF-α decreased from 2.2 (2.0–2.4) at baseline to 2.0 pg/mL (1.8–2.2) (p = 0.02) at follow-up among the TCW. Also the platelet activation biomarkers P-selectin and CD40L decreased significantly [25.4 (24.1–26.6) to 24.4 (22.9–26.0)] ng/mL, p = 0.04 and 125 (114–137) to 105 (96–115) pg/mL, p |
| Databáze: | OpenAIRE |
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