Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids
| Autor: | Reid Oldenburg, Caroline Demangel |
|---|---|
| Přispěvatelé: | Université Paris Diderot - Paris 7 (UPD7), Immunobiologie de l'Infection - Immunobiology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was supported by the 'Marie Skłodowska Curie Actions' of the European Union's Seventh Framework Programme FP7/2007-2013, REA grant agreement n°317057., European Project: 317057,EC:FP7:PEOPLE,FP7-PEOPLE-2012-ITN,HOMIN(2013), Kop, Marie-Luce, Host-microbe interactions in health and disease. Interface with the immune system - HOMIN - - EC:FP7:PEOPLE2013-04-01 - 2017-03-31 - 317057 - VALID, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
[SDV.IMM] Life Sciences [q-bio]/Immunology [SDV]Life Sciences [q-bio] Virulence [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biochemistry Bacterial cell structure Microbiology Mycobacterium Immunomodulation 03 medical and health sciences 0302 clinical medicine Immune system Glycolipid Polyketide synthase [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology [SDV.BC] Life Sciences [q-bio]/Cellular Biology biology Host (biology) Phenolic glycolipids Mycobacteria General Medicine [SDV] Life Sciences [q-bio] 030104 developmental biology Host cell invasion biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Glycolipids Intracellular Immunosuppressive Agents 030215 immunology |
| Zdroj: | Biochimie Biochimie, 2017, ⟨10.1016/j.biochi.2017.03.012⟩ Biochimie, Elsevier, 2017, ⟨10.1016/j.biochi.2017.03.012⟩ |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2017.03.012⟩ |
| Popis: | International audience; Phenolic glycolipids (PGL) are polyketide synthase products that are uniquely produced by a subset of pathogenic mycobacteria and are displayed at the bacterial cell surface, in a strategic position to interfere with host immune cells. Their expression has been associated with enhanced mycobacterial virulence in vivo, and suppression of the inflammatory responses of host phagocytes in vitro. In this review, we will present our current understanding of the mode of operation of PGL, along with functional evidence that demonstrates the evolutionary advantage conferred by PGL production for host cell invasion, intracellular persistence and evasion of host immune and bactericidal responses. |
| Databáze: | OpenAIRE |
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