Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin
| Autor: | Min su Kang, Sarah E. Elmore, H. Andrew Hansen, Bradley H Pollock, Timothy D. Phillips, Lili Tang, Kathy S. Xue, Marisa Rodriguez, Nicole Dierschke, Fernando Guerra, Jia-Sheng Wang, Holly Hayes, Amelia A. Romoser |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Aflatoxin Aflatoxin B1 Health Toxicology and Mutagenesis Placebo-controlled study clinical intervention trial Physiology Toxicology Poisons 0302 clinical medicine Medicine AFB(1)-lysine adduct Cancer education.field_of_study Incidence (epidemiology) Liver Disease calcium montmorillonite clay General Medicine Texas 030220 oncology & carcinogenesis Hepatocellular carcinoma 6.1 Pharmaceuticals Bentonite Aluminum Silicates Female Adult Liver Cancer Population Clinical Trials and Supportive Activities AFB1–lysine adduct Placebo Article 03 medical and health sciences Rare Diseases Food Sciences Double-Blind Method enterosorption Clinical Research Complementary and Integrative Health Humans education Adverse effect Nutrition business.industry Prevention Public Health Environmental and Occupational Health biomarkers Evaluation of treatments and therapeutic interventions General Chemistry medicine.disease Bioavailability Biotechnology 030104 developmental biology Clay Calcium business Digestive Diseases Biomarkers Food Science |
| Zdroj: | Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, vol 33, iss 8 Pollock, BH; Elmore, S; Romoser, A; Tang, L; Kang, MS; Xue, K; et al.(2016). Intervention trial with calcium montmorillonite clay in a south Texas population exposed to aflatoxin. Food Additives and Contaminants-Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 33(8), 1346-1354. doi: 10.1080/19440049.2016.1198498. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4w7025w2 |
| DOI: | 10.1080/19440049.2016.1198498. |
| Popis: | © 2016 Informa UK Limited, trading as Taylor & Francis Group. South Texas currently has the highest incidence of hepatocellular carcinoma (HCC) in the United States, a disease that disproportionately affects Latino populations in the region. Aflatoxin B1 (AFB1) is a potent liver carcinogen that has been shown to be present in a variety of foods in the United States, including corn and corn products. Importantly, it is a dietary risk factor contributing to a higher incidence of HCC in populations frequently consuming AFB1-contaminated diets. In a randomised double-blind placebo controlled trial, we evaluated the effects of a 3-month administration of ACCS100 (refined calcium montmorillonite clay) on serum AFB1–lysine adduct (AFB-Lys) level and serum biochemistry in 234 healthy men and women residing in Bexar and Medina counties, Texas. Participants recruited from 2012 to 2014 received either a placebo, 1.5 g or 3 g ACCS100 each day for 3 months, and no treatment during the fourth month. Adverse event rates were similar across treatment groups and no significant differences were observed for serum biochemistry and haematology parameters. Differences in levels of AFB-Lys at 1, 3 and 4 months were compared between placebo and active treatment groups. Although serum AFB-Lys levels were decreased by month 3 for both treatment groups, the low dose was the only treatment that was significant (p = 0.0005). In conclusion, the observed effect in the low-dose treatment group suggests that the use of ACCS100 may be a viable strategy to reduce dietary AFB1 bioavailability during aflatoxin outbreaks and potentially in populations chronically exposed to this carcinogen. |
| Databáze: | OpenAIRE |
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