Floppy Kid Syndrome Caused by D-Lactic Acidosis in Goat Kids
| Autor: | W. Kähn, Ulrich Bleul, Felix Grimm, Monika Engels, S. Schwantag, H. Stocker, Hans Lutz, Nicole Borel, Marietta Schönmann, L Corboz |
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| Přispěvatelé: | University of Zurich, Bleul, U |
| Rok vydání: | 2006 |
| Předmět: |
Male
10078 Institute of Parasitology medicine.medical_specialty 3400 General Veterinary education 10184 Institute of Veterinary Pathology Anion gap chemistry.chemical_compound Oral administration Internal medicine medicine Animals Retrospective Studies Goat Diseases Sodium bicarbonate 630 Agriculture General Veterinary D-lactic acidosis business.industry Goats Muscle weakness Metabolic acidosis medicine.disease humanities 10187 Department of Farm Animals Sodium Bicarbonate Endocrinology Animals Newborn chemistry 570 Life sciences biology Acidosis Lactic Female Base excess medicine.symptom business human activities Blood Chemical Analysis Kid syndrome |
| Zdroj: | Journal of Veterinary Internal Medicine. 20:1003-1008 |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | BACKGROUND: Goat kids with floppy kid syndrome have metabolic acidosis, muscle weakness, and depression but no dehydration. HYPOTHESIS: D-Lactate is the major component of acidemia in goat kids with floppy kid syndrome. ANIMALS: Fifty-five goat kids with floppy kid syndrome (group F) and 35 clinically healthy goat kids (group C). METHODS: Clinical, biochemical, microbiologic, virologic, parasitologic, and pathologic examinations. RESULTS: The animals in group F had a blood pH of 7.13 +/- 0.11 and a base excess of -17.8 +/- 3.8 mM, which were both lower than the values in the control animals (pH, 7.32 +/- 0.31; base excess, -0.1 +/- 2.7 mM; P < .001). Floppy kids had a significantly larger anion gap than healthy kids (31.2 +/- 3.7 versus 21.5 +/- 8.5 mM; P < .001). The concentration of L-lactate was lower in floppy kids than in healthy kids (0.67 +/- 0.49 versus 1.60 +/- 1.02 mM), but the concentration of D-lactate was higher in floppy kids (7.43 +/- 2.71 versus 0.26 +/- 0.24 mM; P < .001). Intravenous and oral administration of sodium bicarbonate in floppy kids resulted in a significant increase in blood pH and base excess and a decrease in the anion gap (P < .001). In addition, the concentration of L-lactate increased (P = .039). CONCLUSIONS AND CLINICAL IMPORTANCE: Metabolic acidosis in goat kids with floppy kid syndrome is caused by an increase in the plasma concentration of D-lactate. |
| Databáze: | OpenAIRE |
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