High dose rate brachytherapy in early stage squamous-cell carcinoma of the lip
| Autor: | Josefa Samper, Paula Santamaría, Leoncio Arribas, Lorena Díez-Presa, Maria Isabel Tortajada, Juan Bosco Vendrell, Alejandro Mut, M. Santos, Jose Luis Guinot |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Brachytherapy Kaplan-Meier Estimate Disease-Free Survival Lip Neoplasm 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Stage (cooking) Radiation Injuries Aged Retrospective Studies Aged 80 and over Stomatitis business.industry Dose fractionation Soft tissue Retrospective cohort study Radiotherapy Dosage 030206 dentistry General Medicine Middle Aged medicine.disease High-Dose Rate Brachytherapy Surgery Tumor Burden Treatment Outcome 030220 oncology & carcinogenesis Lymphatic Metastasis Lip Neoplasms Carcinoma Squamous Cell Female Dose Fractionation Radiation Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Acta otorrinolaringologica espanola. 67(5) |
| ISSN: | 1988-3013 |
| Popis: | Introduction and goals To analyse the results obtained after treatment of early stage (T1–T2) squamous cell carcinoma of the lip with high dose rate brachytherapy and evaluate the efficacy of this treatment in both local and regional control. Materials and methods Retrospective analysis of the treatments performed at our department from March 1999 to March 2013 with high dose rate brachytherapy with rigid needles. We included 68 patients, 63 men and 5 women; 37 patients (54.4%) presented a T1 tumour, less than or equal to 2 cm, while the other 31 (45.6%) were classified as T2. Median total dose was 45 Gy, with a median dose per fraction of 5 Gy×9 fractions twice a day for 5 days. Results With a mean follow-up of 56.4 months, local control was 96.9%. Stratifying by tumour size, local control of T1 cases was 100%, while T2 achieved 93.2% (2 local recurrences). Regional control at 5 years was 93.8% for T1, and 80.8% for T2. In 11 cases with elective cervical treatment, no regional failure happened. As for toxicity, no patient presented soft tissue, or bone, necrosis. All patients achieved good or excellent cosmetic and functional results. Conclusions High dose rate brachytherapy allows effective, safe treatments for squamous cell carcinoma of the lip, with good aesthetic and functional results. It can be considered a valid alternative for surgery in early stage tumours. |
| Databáze: | OpenAIRE |
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