Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise
| Autor: | Chieh-Chung Liu, Wan Teng Lin, Chin Cheng Hsieh, Chi Chang Huang, Suh Ching Yang, Su Jiun Lin, Shih Yi Huang |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Muscle tissue
Male medicine.medical_specialty Xanthine Oxidase Erythrocytes Medicine (miscellaneous) Physical exercise medicine.disease_cause Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Lycopene Internal medicine Physical Conditioning Animal medicine Animals Xanthine oxidase Muscle Skeletal Peroxidase Analysis of Variance Nutrition and Dietetics biology Myocardium Skeletal muscle Malondialdehyde Carotenoids Glutathione Rats Uric Acid Oxidative Stress medicine.anatomical_structure Endocrinology chemistry Biochemistry Liver Myeloperoxidase Dietary Supplements Models Animal Muscle Fatigue biology.protein Lipid Peroxidation Oxidative stress |
| Zdroj: | The British journal of nutrition. 94(4) |
| ISSN: | 0007-1145 |
| Popis: | Strenuous exercise is known to induce oxidative stress leading to the generation of free radicals. The purpose of the present study was to investigate the effects of lycopene, an antioxidant nutrient, at a relatively low dose (2·6 mg/kg per d) and a relatively high dose (7·8 mg/kg per d) on the antioxidant status of blood and skeletal muscle tissues in rats after exhaustive exercise. Rats were divided into six groups: sedentary control (C); sedentary control with low-dose lycopene (CLL); sedentary control with high-dose lycopene (CHL); exhaustive exercise (E); exhaustive exercise with low-dose lycopene (ELL); exhaustive exercise with high-dose lycopene (EHL). After 30 d, the rats in the three C groups were killed without exercise, but the rats in the three E groups were killed immediately after an exhaustive running test on a motorised treadmill. The results showed that xanthine oxidase (XO) activities of plasma and muscle, and muscular myeloperoxidase (MPO) activity in group E were significantly increased compared with group C. Compared with group E, the elevations of XO and MPO activities of muscle were significantly decreased in group EHL. The malondialdehyde concentrations of plasma and tissues in group E were significantly increased by 72 and 114 %, respectively, compared with those in group C. However, this phenomenon was prevented in rats of the ELL and EHL groups. There was no significant difference in the GSH concentrations of erythrocytes in each group; however, exhaustive exercise resulted in a significant decrease in the GSH content of muscle. In conclusion, these results suggested that lycopene protected muscle tissue from oxidative stress after exhaustive exercise. |
| Databáze: | OpenAIRE |
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