Nucleotide sequence of the genes encoding the canine herpesvirus gB, gC and gD homologues
| Autor: | Limbach Kj, Paoletti E, Conte D, Limbach Mp |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Genes
Viral Molecular Sequence Data Genome Viral Homology (biology) Canine herpesvirus Open Reading Frames Dogs Viral Envelope Proteins Virology Animals Amino Acid Sequence Gene Peptide sequence Herpesviridae chemistry.chemical_classification Genetics biology Base Sequence Sequence Homology Amino Acid Nucleic acid sequence Sequence Analysis DNA biology.organism_classification Molecular biology Amino acid Open reading frame chemistry Glycoprotein |
| Zdroj: | The Journal of general virology. 75 |
| ISSN: | 0022-1317 |
| Popis: | The nucleotide sequence of the genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues was determined. These genes are predicted to encode polypeptides of 879, 459 and 345 amino acids, respectively. Comparison of the predicted amino acid sequences of CHV gB, gC and gD with the homologous sequences from other herpesviruses indicates that CHV is an alphaherpesvirus, a conclusion that is consistent with the previous classification of this virus according to biological properties. Alignment of the homologous gB, gC and gD amino acid sequences indicates that most of the cysteine residues are conserved, suggesting that these glycoproteins possess similar tertiary structures. The nucleotide sequence of the open reading frame downstream from the CHV gC gene was also determined. The predicted amino acid sequence of this putative polypeptide appears to be homologous to a family of proteins encoded downstream from the gC gene in most, although not all, alphaherpesviruses. |
| Databáze: | OpenAIRE |
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