Electrical stimulation of the lateral habenula produces an inhibitory effect on sucrose self-administration
| Autor: | Einav Sudai, Elad Lax, Gal Yadid, Moshe Ben-Tzion, Alexander Friedman, Yahav Dikshtein, Yakov Flaumenhaft, Lital Abraham |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Sucrose Deep brain stimulation Punishment (psychology) medicine.medical_treatment Context (language use) Stimulation Self Administration Article Lesion Rats Sprague-Dawley Cellular and Molecular Neuroscience Reward Internal medicine medicine Animals Reinforcement Pharmacology Habenula Extinction (psychology) Electric Stimulation Rats Endocrinology medicine.symptom Self-administration Psychology Neuroscience Reinforcement Psychology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuropharmacology. 60(2-3) |
| ISSN: | 1873-7064 |
| Popis: | The lateral habenula (LHb) plays a role in prediction of negative reinforcement, punishment and aversive responses. In the current study, we examined the role that the LHb plays in regulation of negative reward responses and aversion. First, we tested the effect of intervention in LHb activity on sucrose reinforcing behavior. An electrode was implanted into the LHb and rats were trained to self-administer sucrose (20%; 16 days) until at least three days of stable performance were achieved (as represented by the number of active lever presses in self-administration cages). Rats subsequently received deep brain stimulation (DBS) of the LHb, which significantly reduced sucrose self-administration levels. In contrast, lesion of the LHb increased sucrose-seeking behavior, as demonstrated by a delayed extinction response to substitution of sucrose with water. Furthermore, in a modified non-rewarding conditioned-place-preference paradigm, DBS of the LHb led to aversion to the context associated with stimulation of this brain region. We postulate that electrical stimulation of the LHb attenuates positive reward-associated reinforcement by natural substances. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect