The CD11b-integrin (ITGAM) and systemic lupus erythematosus
| Autor: | Martyn J. James, Chak Sing Lau, Susanna C. Fagerholm, M MacPherson, C Sevier-Guy |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Arginine
medicine.medical_treatment Phagocytosis Integrin Macrophage-1 Antigen CD18 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors medicine Extracellular Animals Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease Cell adhesion 030304 developmental biology 030203 arthritis & rheumatology 0303 health sciences CD11b Antigen biology business.industry Genetic Variation 3. Good health Cytokine Amino Acid Substitution Integrin alpha M biology.protein Cancer research business |
| Zdroj: | Lupus. 22:657-663 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203313491851 |
| Popis: | Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic variant (rs1143679) which results in an arginine to histidine substitution at position 77 in the extracellular portion of the integrin is associated with disease. It has recently been shown that this amino acid substitution results in a dysfunctional integrin, which is deficient in mediating cell adhesion to integrin ligands, phagocytosis and in addition cannot restrict inflammatory cytokine production in macrophages. In this review, we discuss immunological functions of the Mac-1 integrin and how defects in the genetic variant of Mac-1 may relate to SLE development. |
| Databáze: | OpenAIRE |
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