Osmotic Demyelination Syndrome as the Initial Manifestation of a Hyperosmolar Hyperglycemic State
Autor: | Karla Victoria Rodriguez-Velver, Maria Azucena Zapata-Rivera, Jesús Zacarías Villarreal-Pérez, Juan Montes-Villarreal, René Rodríguez-Gutiérrez, Analy J. Soto-Garcia |
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Rok vydání: | 2014 |
Předmět: |
medicine.medical_specialty
business.industry Urinary system Glasgow Coma Scale Case Report Venous blood Fluid-attenuated inversion recovery medicine.disease Asymptomatic lcsh:RC346-429 Pathophysiology Surgery Anesthesia Hyperosmolar hyperglycemic state Medicine Tonicity medicine.symptom General Agricultural and Biological Sciences business lcsh:Neurology. Diseases of the nervous system |
Zdroj: | Case Reports in Neurological Medicine, Vol 2014 (2014) Case Reports in Neurological Medicine |
ISSN: | 2090-6676 2090-6668 |
Popis: | Osmotic demyelination syndrome (ODS) is a life-threatening demyelinating syndrome. The association of ODS with hyperosmolar hyperglycemic state (HHS) has been seldom reported. The aim of this study was to present and discuss previous cases and the pathophysiological mechanisms involved in ODS secondary to HHS. A 47-year-old man arrived to the emergency room due to generalized tonic-clonic seizures and altered mental status. The patient was lethargic and had a Glasgow coma scale of 11/15, muscle strength was 4/5 in both lower extremities, and deep tendon reflexes were diminished. Glucose was 838 mg/dL; serum sodium and venous blood gas analyses were normal. Urinary and plasma ketones were negative. Brain magnetic resonance revealed increased signal intensity on T2-weighted FLAIR images with restricted diffusion on the medulla and central pons. Supportive therapy was started and during the next 3 weeks the patient progressively regained consciousness and muscle strength and was able to feed himself. At 6-month follow-up, the patient was asymptomatic and MRI showed no residual damage. In conclusion, the association of ODS with HHS is extremely rare. The exact mechanism by which HHS produces ODS still needs to be elucidated, but we favor a rapid hypertonic insult as the most plausible mechanism. |
Databáze: | OpenAIRE |
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