Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity
| Autor: | Rajesh Jayachandran, Xiaolong Liu, Jean Pieters, Vera Studer, Sebastian Rühl, Somdeb BoseDasgupta, Michael Stiess |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gs alpha subunit G protein Biophysics Coronin Biochemistry Cell Line Mice 03 medical and health sciences Structural Biology Cyclin-dependent kinase Cyclic AMP Genetics Animals Phosphorylation Protein kinase A Molecular Biology biology Kinase Chemistry Cyclin-dependent kinase 5 Microfilament Proteins Cyclin-Dependent Kinase 5 Cell Biology Cyclic AMP-Dependent Protein Kinases Cell biology Enzyme Activation 030104 developmental biology biology.protein Signal transduction Protein Binding Signal Transduction |
| Zdroj: | FEBS letters |
| ISSN: | 0014-5793 |
| DOI: | 10.1002/1873-3468.12046 |
| Popis: | Coronins constitute a family of conserved proteins expressed in all eukaryotes that have been implicated in the regulation of a wide variety of cellular activities. Recent work showed an essential role for coronin 1 in the modulation of the cAMP/PKA pathway in neurons through the interaction of coronin 1 with the G protein subtype Gαs in a stimulus-dependent manner, but the molecular mechanism regulating coronin 1-Gαs interaction remains unclear. We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Gαs association and the modulation of cAMP production. Together these results show an essential role for CDK5 activity in promoting the coronin 1-dependent cAMP/PKA pathway. |
| Databáze: | OpenAIRE |
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