The galloyl moiety enhances inhibitory activity of polyphenols against adipogenic differentiation in 3T3-L1 preadipocytes

Autor:	Jinming Peng, Wenjun Wen, Ruifeng Wang, Kaikai Li, Gengsheng Xiao, Chunmei Li
Rok vydání:	2022
Předmět:	PPAR gamma Mice Adipogenesis 3T3-L1 Cells CCAAT-Enhancer-Binding Protein-alpha Animals Polyphenols Cell Differentiation General Medicine Food Science
Zdroj:	Food & Function. 13:5275-5286
ISSN:	2042-650X 2042-6496
DOI:	10.1039/d1fo04179g
Popis:	Previous studies have proved that the characteristic galloyl moiety in polyphenols is crucial for their biological activities. However, whether the presence of the galloyl moiety in the structure of polyphenols has a great contribution to their inhibition of adipogenic differentiation is not clear. Therefore, in this study, seven polyphenols with different galloylation degrees were chosen for exploring the contribution of the galloyl group to the lipid-lowering property of polyphenols and its molecular mechanism. Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARγ and C/EBPα related MAPK signaling pathway, probably
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e63be6f772f7e42d720ecb398efe47 https://doi.org/10.1039/d1fo04179g Zobrazit plný text záznamu