Serum Biomarkers for Early Detection of Hepatocellular Carcinoma Associated with HCV Infection in Egyptian Patients
| Autor: | Abdel-Rahman N. Zekri, Gamal Esmat, Ibtisam Hammad, Hanan Abd El-Haleem Marzouk, Mohammed Mahmoud Nabil, Khaled S. Zachariah, Amira Salah El-Din Youssef, Hanan Abd El-Hafez Hamed, Yasser Mabrouk Bakr, Entsar Abd El-Monaem Ahmed, Yasser Hamada Ahmed Aly, Mahmoud N El-Rouby, Reham Mohamed Gabr |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male Cancer Research medicine.medical_specialty Pathology Carcinoma Hepatocellular Cirrhosis Epidemiology Early detection Hepacivirus Gastroenterology Serology Young Adult Serum biomarkers Internal medicine Biomarkers Tumor medicine Humans Interleukin 8 Aged Neoplasm Staging Aged 80 and over business.industry Liver Neoplasms Public Health Environmental and Occupational Health Curve analysis Middle Aged Prognosis medicine.disease Hepatitis C Early Diagnosis ROC Curve Oncology Case-Control Studies Hepatocellular carcinoma Egypt Female Alpha-fetoprotein business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:1281-1287 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2015.16.3.1281 |
| Popis: | Background: Early detection of hepatocellular carcinoma using serological markers with better sensitivity and specificity than alpha fetoprotein (AFP) is needed. Aims: The aim of this study was to evaluate the diagnostic value of serum sICAM-1, β-catenin, IL-8, proteasome and sTNFR-II in early detection of HCC. Materials and Methods: Serum levels of IL-8, sICAM-1, sTNFR-II, proteasome and β-catenin were measured by ELISA assay in 479 serum samples from 192 patients with HCC, 96 patients with liver cirrhosis (LC), 96 patients with chronic hepatitis C (CHC) and 95 healthy controls. Results: Serum levels of proteasome, sICAM-1, β-catenin and αFP were significantly elevated in HCC group compared to other groups (P-value |
| Databáze: | OpenAIRE |
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