Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Autor: Yu Hu, Hui Ma, Boshen Pan, Jian Gao, Xuejuan Jin, Xin Gao, Naiqing Zhao, Xiaoming Li, Huandong Lin, Wanyuan He
Rok vydání: 2017
Předmět:
Blood Glucose
Carotid Artery Diseases
Male
Non-HDL-C
Carotid atherosclerosis
China
medicine.medical_specialty
Clinical chemistry
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Blood Pressure
030209 endocrinology & metabolism
Clinical nutrition
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
03 medical and health sciences
0302 clinical medicine
Endocrinology
Asian People
Internal medicine
medicine
Humans
cardiovascular diseases
Elderly adults
Aged
Biochemistry
medical
business.industry
Research
Cholesterol
HDL
Biochemistry (medical)
Non high density lipoprotein cholesterol
Cholesterol
LDL
Middle Aged
Carotid intima-media thickness (CIMT)
Anthropometry
Atherosclerosis
Carotid plaque
Plaque
Atherosclerotic
Cross-Sectional Studies
Quartile
Cardiology
Female
lipids (amino acids
peptides
and proteins)
business
Lipidology
Zdroj: Lipids in Health and Disease
ISSN: 1476-511X
DOI: 10.1186/s12944-017-0451-4
Popis: Background We investigate whether non–high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults. Methods A total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed. Results The mean values of non-HDL-C were 3.4 ± 0.8 mmol/l and 3.6 ± 0.9 mmol/l for male and female subjects, respectively. Compared with female subjects with non-HDL-C in the first quartile, female subjects with non-HDL-C in the fourth quartile had 1.317-fold increased risks for carotid plaques after adjusting for conventional cardiovascular disease (CVD) risk factors and increasing quartiles of all lipid levels. Non-HDL-C was positively associated with the CIMT after adjusting for CVD risk factors in female subjects (β = 0.062, P = 0.034). Conclusions These results suggest that non-HDL-C is independently associated with carotid atherosclerosis in normotensive and euglycemic females.
Databáze: OpenAIRE
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