Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine

Autor: Staffan Schmidt, Joseph T. Coyle, Micaela Galante, Glenn Dallérac, Kevin C. F. Fone, Silvia Sacchi, Grégoire Levasseur, Jan Kehr, David J. G. Watson, Brigitte Potier, Xia Li, Pierre Lecouflet, Alain M. Gardier, Loredano Pollegioni, Thu Ha Pham, Rachel Asselot, Angelo Contarino, Pascal Fossat, Jean-Pierre Mothet, Millan Mark, Andrey Besedin, Ginetta Collo, Thomas Freret, Jean-Michel Rivet, Nadege Morisot
Přispěvatelé: Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lumière, Matière et Interfaces (LuMIn), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Saclay (COmUE), University of Nottingham, UK (UON), Pronexus Analytical AB, Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches SERVIER (IRS), Harvard Medical School [Boston] (HMS), McLean Hospital [Belmont, Ma.], Università degli Studi di Brescia = University of Brescia (UniBs), Faculté de Pharmacie [Châtenay-Malabry], Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay, The Protein Factory 2.0, Dipartimento di Biotecnologie e Scienze della Vita, Laboratoire de Neuropharmacologie, Centre de Recherche en Epidémiologie et Santé des Populations, School of Life Sciences, Queen's Medical Centre, Centre for Thérapeutique Innovation in Neuropsychiatry, Department of Psychiatry, Harvard Medical School, USA, Laboratory for Psychiatric and Molecular Neuroscience, Università degli Studi di Brescia [Brescia], The ProFactory 2.0, Dipartimento di Biotecnologie e Scienze della Vita, Universitá degli Studi dell’Insubria, Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
serine racemase knockout mice
D1- and D2-type receptors
NMDA receptors
d-serine
schizophrenia
Dopamine
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Racemases and Epimerases
Glutamic Acid
Prefrontal Cortex
Biology
Receptors
N-Methyl-D-Aspartate
Synaptic Transmission
Receptors
Dopamine
Mice
03 medical and health sciences
Glutamatergic
0302 clinical medicine
Neuromodulation
Serine
medicine
Animals
Prefrontal cortex
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Mice
Knockout
0303 health sciences
Multidisciplinary
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Dopaminergic
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Long-term potentiation
D-serine
Schizophrenia
Serine racemase knockout mice
Biological Sciences
medicine.anatomical_structure
Synaptic plasticity
NMDA receptor
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Zdroj: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (23), pp.e2023750118. ⟨10.1073/pnas.2023750118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, ⟨10.1073/pnas.2023750118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (23), pp.e2023750118. ⟨10.1073/pnas.2023750118⟩
Proc Natl Acad Sci U S A
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.2023750118⟩
Popis: International audience; Prefrontal control of cognitive functions critically depends upon glutamatergic transmission and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine. Yet whether the NMDA receptor coagonist d -serine is implicated in the dopamine–glutamate dialogue in the prefrontal cortex (PFC) and other brain areas remains unexplored. Here, using electrophysiological recordings, we show that d -serine is required for the fine-tuning of glutamatergic neurotransmission, neuronal excitability, and synaptic plasticity in the PFC through the actions of dopamine at D 1 and D 3 receptors. Using in vivo microdialysis, we show that D 1 and D 3 receptors exert a respective facilitatory and inhibitory influence on extracellular levels and activity of d -serine in the PFC, with actions expressed primarily via the cAMP/protein kinase A (PKA) signaling cascade. Further, using functional magnetic resonance imaging (fMRI) and behavioral assessment, we show that d -serine is required for the potentiation of cognition by D 3 R blockade as revealed in a test of novel object recognition memory. Collectively, these results unveil a key role for d -serine in the dopaminergic neuromodulation of glutamatergic transmission and PFC activity, findings with clear relevance to the pathogenesis and treatment of diverse brain disorders involving alterations in dopamine–glutamate cross-talk.
Databáze: OpenAIRE
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