Bi-Catalyzed 1,2-Reactivity of Spirocyclopropyl Oxindoles with Dithianediol: Access to Spiroheterocycles

Autor:	Subhradeep Kar, Tanumay Sarkar, Prabhat K. Maharana, Ankur K. Guha, Tharmalingam Punniyamurthy
Rok vydání:	2022
Předmět:	Cyclopropanes Indoles Organic Chemistry Physical and Theoretical Chemistry Biochemistry Catalysis Oxindoles
Zdroj:	Organic Letters. 24:4965-4970
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c01928
Popis:	The efficient Bi-catalyzed 1,2-reactivity of spirocyclopropyl oxindoles has been disclosed with dithianediols as the sulfur surrogate to furnish spiroheterocycles at moderate temperature. The procedure provides a potential approach for the construction of spirotetrahydrothiophene scaffolds with functional group diversity. The catalytic 1,2-reactivity of cyclopropanes, mechanistic studies using density functional theory studies, diastereoselectivity, and additive-free mild conditions are the important practical features.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e3c10d813a7fd8f03522c5d37f1837 https://doi.org/10.1021/acs.orglett.2c01928 Zobrazit plný text záznamu