Anti-Angiotensin II Type 1 Receptor and Anti-Endothelial Cell Antibodies
| Autor: | Annette M. Jackson, Mary S. Leffell, Duska Dragun, Robert A. Montgomery, Serena M. Bagnasco, Edward S. Kraus, Andrea A. Zachary, Mary Carmelle Philogene |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Graft Rejection Male Pathology medicine.medical_specialty Biopsy Cell 030232 urology & nephrology Enzyme-Linked Immunosorbent Assay Human leukocyte antigen 030230 surgery Kidney Receptor Angiotensin Type 1 Isoantibodies 03 medical and health sciences 0302 clinical medicine HLA Antigens medicine Humans Receptor Aged Autoantibodies Transplantation biology medicine.diagnostic_test business.industry Histocompatibility Testing Graft Survival Autoantibody Endothelial Cells Original Clinical Science—General Middle Aged Allografts Kidney Transplantation Angiotensin II Cross-Sectional Studies Treatment Outcome medicine.anatomical_structure Histocompatibility Immunology biology.protein Female Antibody business |
| Zdroj: | Transplantation |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0000000000001231 |
| Popis: | Background This is a cross-sectional study designed to evaluate the histologic characteristics of graft injury in the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). Methods Non-HLA antibody testing was included in the posttransplant evaluation for 70 kidney recipients. Biopsies were performed for cause for 47 patients and as protocol for the remaining 23 patients. Biopsy-proven rejection was defined according to the Banff 2009-2013 criteria. AT1R-Ab was measured on an ELISA platform. Patients were divided into 3 groups based on AT1R-Ab levels (>17, 10-17, and 17 U/ml, although this did not reach statistical significance (P = 0.07). Conclusions The data show an association between non-HLA antibodies detected in the ECXM and AT1R ELISA and microvascular injury observed in antibody mediated rejection. The histologic characteristics of kidney graft injury are examined in terms of the presence of anti-angiotensin II type 1 receptor antibody (AT1R-Ab) and anti-endothelial cell antibody (AECA). The presence of AECA or AT1R-Ab correlates with microvascular injury observed in antibody-mediated rejection. |
| Databáze: | OpenAIRE |
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