The Gut Microbiota and Traditional Chinese Medicine: A New Clinical Frontier on Cancer
| Autor: | Yong-Hu Qiang, Ya Ling Chen, Jian Wu, Xi Zou, Qingmin Sun, Yan-Zhen Chen, Shenlin Liu, Xin-Tian Xu, Jia-Lei Tao, Xing-Xing Zhang, Mengyun Yuan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Plants Medicinal biology Clinical Biochemistry Cancer Traditional Chinese medicine Gut flora Bioinformatics medicine.disease biology.organism_classification digestive system 030226 pharmacology & pharmacy Gastrointestinal Microbiome 03 medical and health sciences 0302 clinical medicine Neoplasms 030220 oncology & carcinogenesis Drug Discovery medicine Humans Molecular Medicine Medicine Chinese Traditional Potential mechanism Drugs Chinese Herbal |
| Zdroj: | Current Drug Targets. 22:1222-1231 |
| ISSN: | 1389-4501 |
| Popis: | Gut microbiota is a complex microecosystem, which is called the second genome of the human body. Herbal medicine can balance tumor-suppressing bacteria and tumor-promoting bacteria and exert its anti-cancer effect by regulating gut microbiota. Traditional Chinese medicine (TCM) has a history of thousands of years in prevention and treatment of diseases in China. In recent decades, TCM has been shown to have an obvious advantage in prolonging the survival time and improving the living quality of patients with cancer. Notably, gut microbiota has become a new pathway to understanding TCM. In this review, we will focus on gut microbiota and tumor progression, especially the diversity, functionality and metabolites of gut microbiota affected by TCM in various cancer. We will also discuss the potential mechanism of gut microbiota for exploring TCM in anti-cancer effect. This article aims to comprehensively review the anti-cancer research of TCM by regulating gut microbiota, and address future perspectives and challenges of gut microbiota in TCM intervention for cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|