Shiga Toxin Stx2 Production Is Promoted by Enrofloxacin in Experimental In Vitro–Selected Mutants of Escherichia coli O157:H7 Resistant to Fluoroquinolones
| Autor: | Claire Maurer, Danièle Meunier, Jean-Yves Madec |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.drug_class
animal diseases Mutant Antibiotics Cattle Diseases Enzyme-Linked Immunosorbent Assay Drug resistance Escherichia coli O157 medicine.disease_cause Shiga Toxin 2 Applied Microbiology and Biotechnology Microbiology fluids and secretions STX2 Drug Resistance Bacterial medicine Enrofloxacin Animals Escherichia coli Escherichia coli Infections biology Shiga toxin biochemical phenomena metabolism and nutrition In vitro Anti-Bacterial Agents Mutation Food Microbiology biology.protein bacteria Cattle Animal Science and Zoology Fluoroquinolones Food Science medicine.drug |
| Zdroj: | Foodborne Pathogens and Disease. 6:257-259 |
| ISSN: | 1556-7125 1535-3141 |
| DOI: | 10.1089/fpd.2008.0165 |
| Popis: | Enrofloxacin-resistant mutants of Stx2-producing Escherichia coli O157:H7 from cattle were selected. Mutants produced threefold higher Stx2 levels than native strains after induction with enrofloxacin. Mutants were also inducible using hundredfold higher enrofloxacin concentrations than the ones used for native strains. These results suggest that Escherichia coli O157:H7 from cattle may become more frequently pathogenic to humans as a side effect of the increasing use of veterinary fluoroquinolones. |
| Databáze: | OpenAIRE |
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