Antifatigue Effects of Panax ginseng C.A. Meyer: A Randomised, Double-Blind, Placebo-Controlled Trial
| Autor: | Jong-Min Han, Nam-Hun Lee, Jung-Hyo Cho, Sa-ra Yoo, Yo-Chan Ahn, Jin-Seok Lee, Hyeong-Geug Kim, Chang-Gue Son |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Non-Clinical Medicine Glutathione reductase Placebo-controlled study lcsh:Medicine Global Health Social and Behavioral Sciences Gastroenterology Antioxidants law.invention Placebos Ginseng chemistry.chemical_compound law Malondialdehyde Pathology Human Performance Medicine Psychology Prospective Studies lcsh:Science Chromatography High Pressure Liquid Fatigue chemistry.chemical_classification Multidisciplinary Evidence-Based Medicine Traditional medicine Glutathione peroxidase Drug Information Middle Aged Catalase Glutathione Mental Health Glutathione Reductase Female Research Article Adult medicine.medical_specialty Drugs and Devices Drug Research and Development Visual analogue scale Clinical Research Design Psychological Stress Panax Placebo Young Adult Complementary and Alternative Medicine Adverse Reactions Double-Blind Method Diagnostic Medicine Internal medicine Humans Clinical Trials Aged Behavior Glutathione Peroxidase business.industry Plant Extracts Superoxide Dismutase lcsh:R Oxidative Stress chemistry lcsh:Q business Phytotherapy Reactive Oxygen Species Biomarkers General Pathology |
| Zdroj: | PLoS ONE PLOS ONE(8): 4 PLoS ONE, Vol 8, Iss 4, p e61271 (2013) |
| ISSN: | 1932-6203 |
| Popis: | UNLABELLED: The present study investigated the antifatigue effects of Panax ginseng C.A. Meyer in 90 subjects (21 men and 69 women) with idiopathic chronic fatigue (ICF) in a randomised, double-blind, placebo-controlled and parallel designed trial. A bespoke 20% ethanol extract of P. ginseng (1 g or 2 g day(-1)) or a placebo was administered to each group for 4 weeks, and then fatigue severity was monitored using a self-rating numeric scale (NRS) and a visual analogue scale (VAS) as a primary endpoint. Serum levels of reactive oxygen species (ROS), malondialdehyde (MDA), total glutathione (GSH) contents and glutathione reductase (GSH-Rd) activity were determined. After 4-week, P. ginseng administration decreased the total NRS score, but they were not statistically significant compared with placebo (P>0.05). Mental NRS score was significantly improved by P. ginseng administrations as 20.4 ± 5.0 to 15.1 ± 6.5 [95% CI 2.3 ~ 8.2] for 1 g and 20.7 ± 6.3 to 13.8 ± 6.2 [95% CI -0.1 ~ 4.2] for 2 g compared with placebo 20.9 ± 4.5 to 18.8 ± 2.9 [95% CI 4.1 ~ 9.9, P |
| Databáze: | OpenAIRE |
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