Cytosolic levels of an estrogen-induced breast cancer-associated peptide (TFF1/pS2) in colorectal cancer: clinical significance and relationship with steroid receptors
| Autor: | María D. Corte, Francisco J. Vizoso, M T Allende, M. G. Corte, M. C. Fagilde, M. Bongera, García-Muñiz Jl, R. Gava |
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| Rok vydání: | 2004 |
| Předmět: |
0301 basic medicine
Cancer Research Time Factors Colorectal cancer Clinical Biochemistry Mammary gland Estrogen receptor Peptide 0302 clinical medicine Cytosol Intestinal Mucosa skin and connective tissue diseases Receptor Child chemistry.chemical_classification Aged 80 and over Middle Aged Prognosis medicine.anatomical_structure Oncology Receptors Estrogen 030220 oncology & carcinogenesis Child Preschool Colonic Neoplasms Trefoil Factor-1 Colorectal Neoplasms Receptors Progesterone hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty Adolescent medicine.drug_class Breast Neoplasms Biology Disease-Free Survival Pathology and Forensic Medicine 03 medical and health sciences Breast cancer Internal medicine medicine Humans RNA Messenger Aged Neoplasm Staging Messenger RNA Rectal Neoplasms Tumor Suppressor Proteins Proteins medicine.disease Survival Analysis 030104 developmental biology Endocrinology chemistry Estrogen Follow-Up Studies |
| Zdroj: | The International journal of biological markers. 18(4) |
| ISSN: | 0393-6155 |
| Popis: | Background The Trefoil Factor 1 (TFF1/pS2), a peptide consisting of 60 amino acids, is the most abundant estrogen-induced messenger RNA in MCF-7 breast cancer cells and is also expressed by colorectal carcinomas. The objective of this work was to evaluate the cytosolic TFF1 content in colorectal carcinomas, its possible relationship with estrogen and progesterone receptors as well as with clinicopathological tumor parameters, and its potential prognostic significance. Methods Cytosolic TFF1 levels were examined by immunoradiometric assay in 178 patients with resectable colorectal cancer. The mean follow-up period was 32 months. Results There was a wide variability of cytosolic TFF1 levels in tumor-surrounding mucosa samples (0.09-42.5 ng/mg protein) as well as in tumors (0.01-270 ng/mg protein). Comparison of paired mucosa and carcinoma samples showed significantly higher TFF1 levels in tumors (mean: 17.1 ng/mg protein) than in mucosa samples (10 ng/mg protein) (p=0.027). TFF1 levels were significantly higher in mucosa samples surrounding distal colon and rectal tumors (p=0.0001) and in tumor samples obtained from older patients (p=0.007). However, there were no significant differences in tumor TFF1 levels with respect to clinicopathological parameters such as the patient's sex, tumor location, stage, histological grade, ploidy, S-phase, or tumor estrogen and progesterone receptors. In addition, there was no significant relationship between tumor TFF1 levels and disease outcome. Conclusions TFF1 may play an as yet undetermined role in the tumorigenesis of colorectal carcinomas. However, cytosolic levels of TFF1 do not seem to have any prognostic significance in colorectal carcinomas. |
| Databáze: | OpenAIRE |
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