Application of a stretched-exponential model for morphometric analysis of accelerated diffusion-weighted 129Xe MRI of the rat lung
| Autor: | Hacene Serrai, Alexei Ouriadov, Elaine Stirrat, Andras A Lindenmaier, Giles E. Santyr, Matthew S. Fox |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Biophysics Lung injury 030218 nuclear medicine & medical imaging Scan time Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine medicine Animals Radiology Nuclear Medicine and imaging Diffusion (business) Lung Retrospective Studies Radiological and Ultrasound Technology business.industry Magnetic Resonance Imaging Rats Exponential function Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Morphometric analysis Xenon Isotopes Nuclear medicine business |
| Zdroj: | Magnetic Resonance Materials in Physics, Biology and Medicine. 34:73-84 |
| ISSN: | 1352-8661 0968-5243 |
| DOI: | 10.1007/s10334-020-00860-6 |
| Popis: | Diffusion-weighted, hyperpolarized 129Xe MRI is useful for the characterization of microstructural changes in the lung. A stretched exponential model was proposed for morphometric extraction of the mean chord length (Lm) from diffusion-weighted data. The stretched exponential model enables accelerated mapping of Lm in a single-breathhold using compressed sensing. Our purpose was to compare Lm maps obtained from stretched-exponential model analysis of accelerated versus unaccelerated diffusion-weighted 129Xe MRI data obtained from healthy/injured rat lungs. Lm maps were generated using a stretched-exponential model analysis of previously acquired fully sampled diffusion-weighted 129Xe rat data (b values = 0 … 110 s/cm2) and compared to Lm maps generated from retrospectively undersampled data simulating acceleration factors of 7/10. The data included four control rats and five rats receiving whole-lung irradiation to mimic radiation-induced lung injury. Mean Lm obtained from the accelerated/unaccelerated maps were compared to histological mean linear intercept. Accelerated Lm estimates were similar to unaccelerated Lm estimates in all rats, and similar to those previously reported ( |
| Databáze: | OpenAIRE |
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