Regiospecific solid-phase strategy to N7-substituted purines and its application to 8-azapurines and [I]-condensed purines

Autor:	Yulin Lam, Mark Kheng Chuan Tan, Han Fu
Rok vydání:	2007
Předmět:	Magnetic Resonance Spectroscopy Chemistry Purines Phase (matter) Regioselectivity General Chemistry Purine metabolism Hydroxylamines Combinatorial chemistry Mass Spectrometry
Zdroj:	Journal of combinatorial chemistry. 9(5)
ISSN:	1520-4766
Popis:	A highly regioselective and traceless solid-phase route to 1,7,8-trisubstituted purines has been developed. This methodology could be extended to the preparation of 8-azapurines and [i]-condensed purines. A representative set of 17 purines, azapurines, and [i]-condensed purines was synthesized. This paper also describes a mild method to prepare the p-benzyloxybenzylamine (BOBA) resin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d9e7194ca9a2e6e626fc7b4cd8df41 https://pubmed.ncbi.nlm.nih.gov/17688325 Zobrazit plný text záznamu