The effect of local converting enzyme inhibition on the dilator response to substance P in the human forearm
| Autor: | DJ Webb, N Benjamin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Bradykinin Vasodilation Substance P Angiotensin-Converting Enzyme Inhibitors chemistry.chemical_compound Enalapril Internal medicine medicine.artery Renin–angiotensin system medicine Humans Pharmacology (medical) Brachial artery Pharmacology biology Dose-Response Relationship Drug Chemistry Angiotensin-converting enzyme Forearm Endocrinology Regional Blood Flow Dilator biology.protein medicine.drug Research Article |
| Zdroj: | British journal of clinical pharmacology. 29(6) |
| ISSN: | 0306-5251 |
| Popis: | It has been proposed that angiotensin converting enzyme (ACE) may play a part in the metabolism of substance P. Reduced metabolism following treatment with ACE inhibitors may cause accumulation of substance P to produce the adverse effect of cough. It has been shown in this study that, in contrast to angiotensin I and bradykinin, inhibition of local vascular ACE does not interfere with the vascular effects of substance P on forearm resistance vessels when this peptide is infused into the brachial artery of normal volunteers. These results suggest that endothelial ACE plays little part in the metabolism of intravascular substance P. |
| Databáze: | OpenAIRE |
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