Kinetochore–microtubule interactions in chromosome segregation: lessons from yeast and mammalian cells
| Autor: | Marira R. Renjith, Tapas Manna, Geethu Emily Thomas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Saccharomyces cerevisiae Biology Microtubules Biochemistry Cell Physiological Phenomena Chromosome segregation Kinetochore microtubule 03 medical and health sciences 0302 clinical medicine Microtubule Chromosome Segregation Yeasts Animals Humans Kinetochores Molecular Biology Mitosis Structural organization Kinetochore Cell Biology Yeast Cell biology Spindle apparatus 030104 developmental biology 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Biochemical Journal. 474:3559-3577 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bcj20170518 |
| Popis: | Chromosome congression and segregation require robust yet dynamic attachment of the kinetochore with the spindle microtubules. Force generated at the kinetochore–microtubule interface plays a vital role to drive the attachment, as it is required to move chromosomes and to provide signal to sense correct attachments. To understand the mechanisms underlying these processes, it is critical to describe how the force is generated and how the molecules at the kinetochore–microtubule interface are organized and assembled to withstand the force and respond to it. Research in the past few years or so has revealed interesting insights into the structural organization and architecture of kinetochore proteins that couple kinetochore attachment to the spindle microtubules. Interestingly, despite diversities in the molecular players and their modes of action, there appears to be architectural similarity of the kinetochore-coupling machines in lower to higher eukaryotes. The present review focuses on the most recent advances in understanding of the molecular and structural aspects of kinetochore–microtubule interaction based on the studies in yeast and vertebrate cells. |
| Databáze: | OpenAIRE |
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