Evaluation of Allergenic, Immunogenic, and Skin-Irritant Effects of Deicing Chemicals in Warm-Blooded Animals
| Autor: | I A Kryatov, A K Makovetskaya, O V Mislavsky, M.A. Vodyanova, I.S. Evseeva, S B Chudakova, O.V. Ushakova |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Glycerol Male Skin irritant Guinea Pigs Modified method Transportation General Biochemistry Genetics and Molecular Biology Russia 03 medical and health sciences Mice 0302 clinical medicine High doses Medicine Animals Humans Hypersensitivity Delayed Skin Mice Inbred BALB C integumentary system Deicing chemicals business.industry General Medicine Allergens Immunity Humoral Rats Hypersensitivity reaction 030104 developmental biology Skin irritation Warm-blooded Humoral immunity Immunology Irritants Female Salts Rabbits business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 167(5) |
| ISSN: | 1573-8221 |
| Popis: | We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods. |
| Databáze: | OpenAIRE |
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