A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Autor:	Thomas S. Moody, Silvia Anselmi, Daniele Castagnolo, Siyu Liu, Sarah M. Barry, Seong Heun Kim
Rok vydání:	2021
Předmět:	Solvent Dual role Chemistry Reagent Organic Chemistry Substrate (chemistry) Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Environmentally friendly
Zdroj:	Organic & Biomolecular Chemistry. 19:156-161
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d0ob01966f
Popis:	A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d58479d7a209c198b75ab32ebdd063 https://doi.org/10.1039/d0ob01966f Zobrazit plný text záznamu