The effects of adiposity and alcohol use disorder on adipokines and biomarkers of inflammation in depressed patients
| Autor: | Olli Kampman, Onni Niemelä, Mari Archer, Esa Leinonen, Eeva Moilanen, Mari Hämäläinen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Alcohol Drinking Adipose tissue Adipokine Alcohol use disorder Body Mass Index 03 medical and health sciences 0302 clinical medicine Adipokines Internal medicine mental disorders medicine Humans Resistin Longitudinal Studies Obesity Biological Psychiatry Depression (differential diagnoses) Adiposity Inflammation Adiponectin Depression business.industry Middle Aged medicine.disease 030227 psychiatry Alcoholism Psychiatry and Mental health Endocrinology Cytokines Female business Body mass index Biomarkers 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Psychiatry Research. 264:31-38 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2018.03.073 |
| Popis: | Patients with depression and alcohol use disorder frequently present with elevated markers of inflammation. Adipose tissue may function as a source for inflammation, yet the interplay between adiposity, alcohol use and depression has remained unknown. We examined 242 patients, referred to treatment for depressive symptoms, and followed for a period of 6 months. The assessments included screening for alcohol use and measurements of body mass index, serum adiponectin, leptin, resistin, progranulin, hs-CRP, IL-6 and MCP-1 at baseline and after 6 months of treatment. During follow-up, mean MADRS and AUDIT scores decreased significantly, whereas BMI increased. The changes in the levels of cytokines and adipokines were influenced by alcohol consumption and adiposity in a gender-dependent manner. The presence of AUD seemed to particularly influence the levels of cytokines. The levels of IL-6, hs-CRP, progranulin, and leptin differed between AUD and non-AUD groups at baseline, but no longer at 6 months. Baseline levels of leptin and resistin were higher in women and changes occurring in leptin, progranulin, and adiponectin were more notable in women. The data indicates significant gender-dependent interactions between depression, alcohol and mediators of inflammation, which should be considered in studies on the pathogenesis of depression and its comorbidities. |
| Databáze: | OpenAIRE |
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