Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells
| Autor: | Tomiichiro Oda, Yoshiko Onozawa, Tomoaki Komai |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Exacerbation T-Lymphocytes T cell Arthritis Inflammation Biology Methylation Antibodies Receptors G-Protein-Coupled TCIRG1 Gene Knockout Techniques Mice medicine Animals Hypersensitivity Delayed Receptor Collagen Type II Pharmacology T-cell receptor Serum Albumin Bovine medicine.disease Arthritis Experimental Mice Inbred C57BL medicine.anatomical_structure Knockout mouse Immunology Cattle medicine.symptom |
| Zdroj: | European Journal of Pharmacology. 654:315-319 |
| ISSN: | 0014-2999 |
| Popis: | T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor identified by differential mRNA display during thymocyte apoptosis induced by T cell receptor engagement. To examine the physiological role of an orphan G-protein-coupled receptor TDAG8 in inflammation, we studied various immune-mediated inflammatory disease models using TDAG8-deficient mice. We found that TDAG8-deficient mice showed significant exacerbation of anti-type II collagen antibody-induced arthritis and delayed-type hypersensitivity, and showed a slight exacerbation of collagen-induced arthritis. These results suggest that TDAG8 acts as a negative regulator of inflammation. |
| Databáze: | OpenAIRE |
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