A prospective longitudinal population-based study of clinical miscarriage in an urban Swedish population
| Autor: | Ian Milsom, B Fridén, F Blohm |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Population Abortion Body Mass Index Miscarriage Age Distribution Pregnancy Humans Medicine Prospective cohort study education Exercise Sweden education.field_of_study Ectopic pregnancy business.industry Obstetrics Smoking Pregnancy Outcome Urban Health Obstetrics and Gynecology medicine.disease Abortion Spontaneous Contraceptives Oral Combined Reproductive Medicine Cohort Female Epidemiologic Methods business Live birth |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 115:176-183 |
| ISSN: | 1470-0328 |
| Popis: | Objective To describe the incidence of clinical miscarriage and to investigate the factors influencing the occurrence of clinical miscarriage. Design Prospective study with both cross-sectional and longitudinal comparisons. Setting City of Goteborg, Sweden. Population Population-based study in cohorts of 19-year-old women followed longitudinally. Main outcome measures Incidence of miscarriage and pregnancy outcome. Material and methods A postal questionnaire was sent to women born in 1962 and resident in the city of Goteborg in 1981 (n= 656) regarding pregnancy outcome, clinical miscarriage and other reproductive health factors. Responders in 1981 were contacted again and requested to answer a similar questionnaire every fifth year up to 2001. The same process was repeated in 1991 with women born in 1972 (n= 780) with follow up of these responders in 1996 and 2001. A third cohort of 19-year-old women born in 1982 (n= 666) was interviewed in 2001. The self-reported pregnancy data were verified from hospital files. Results Complete data were available for 341 women born in 1962 and assessed up to the age of 39 years (ever pregnant, n= 320, 94%). There were in total 887 pregnancies (live birth, n= 590, 67%; miscarriage, n= 108, 12%; legal abortion, n= 173, 20% and ectopic pregnancy, n= 16, 2%). Of the 320 ‘ever pregnant’ women, 80 women (25%) had experienced a miscarriage. 76.3% had experienced one miscarriage, 16.3% had two miscarriages and 7.4% had three or more miscarriages. The clinical miscarriage rates in women at different ages were as follows: 20–24 years 13.5%, 25–29 years 12.3%, 30–34 years 10.3% and 35–39 years 17.5%. The corresponding miscarriage rate in the 1972 cohort followed from 19 to 29 years of age was 11%, and in the 1982 cohort assessed at 19 years of age, the miscarriage rate was 9%. No risk factor for miscarriage could be reliably identified. Conclusions Clinical miscarriage constituted 12% of all pregnancies, and one in four women who had been pregnant up to 39 years of age had experienced a miscarriage. Three or more miscarriages were experienced by 7.4%. The occurrence of a miscarriage was not influenced by the order of the pregnancy. |
| Databáze: | OpenAIRE |
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