Relapse of T-cell all after stem cell transplant presenting as hypertrophic cardiomyopathy: The value of non-invasive diagnostic imaging in detecting cardiac leukemia
| Autor: | Nobuhiro Suzuki, Motoki Takamuro, Hiroyuki Tsutsumi, Tsukasa Hori, Naoki Hatakeyama, Nobuo Mizue |
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| Rok vydání: | 2005 |
| Předmět: |
Diagnostic Imaging
Pathology medicine.medical_specialty Adolescent Pleural effusion Cardiomyopathy Leukemic Infiltration Recurrence hemic and lymphatic diseases Acute lymphocytic leukemia medicine Humans Leukemia-Lymphoma Adult T-Cell Radionuclide Imaging business.industry Myocardium Hypertrophic cardiomyopathy Hematology Cardiomyopathy Hypertrophic medicine.disease Magnetic Resonance Imaging Tacrolimus Transplantation Leukemia surgical procedures operative medicine.anatomical_structure Oncology Pediatrics Perinatology and Child Health Female Bone marrow Tomography X-Ray Computed business Stem Cell Transplantation |
| Zdroj: | Pediatric Blood & Cancer. 46:108-111 |
| ISSN: | 1545-5017 1545-5009 |
| DOI: | 10.1002/pbc.20409 |
| Popis: | We describe a 14-year-old female with acute lymphoblastic leukemia (ALL) with a mediastinal mass at diagnosis who developed hypertrophic cardiomyopathy (HC) after stem cell transplantation (SCT). During refractory relapse after SCT using bone marrow from her HLA-matched sibling, she underwent whole thorax irradiation because of pleural effusion and a recurrent mediastinal mass. After a second SCT using peripheral blood from the same donor, she developed HC suspected to be related to tacrolimus. However, isolated cardiac relapse was finally diagnosed by several non-invasive imaging techniques. Cardiac irradiation resolved her cardiac failure, though she eventually developed progressive and fatal hematological disease. |
| Databáze: | OpenAIRE |
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