DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate
| Autor: | Martin D. Crespi, Alberto Baldi, Juan P. Radicella, Juan Carlos Calvo, Eduarde H. Charreau |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Stimulation Testicle Peptide hormone In Vitro Techniques Biochemistry chemistry.chemical_compound Endocrinology In vivo Internal medicine medicine Cyclic AMP Animals Cyclic adenosine monophosphate Testosterone Molecular Biology Leydig cell biology Topoisomerase Intracellular Signaling Peptides and Proteins Leydig Cells Rats Inbred Strains Luteinizing Hormone Molecular biology Rats medicine.anatomical_structure chemistry DNA Topoisomerases Type I biology.protein Luteinizing hormone Carrier Proteins Gonadotropins |
| Zdroj: | Molecular and cellular endocrinology. 53(3) |
| ISSN: | 0303-7207 |
| Popis: | The action of luteinizing hormone on topoisomerase I activity from rat Leydig cells was studied. Stimulation of the enzyme was observed after long-term (24 and 48 h) gonadotrophin treatment in in vivo experiments. No change could be detected for shorter times than 12 h using two different experimental approaches. Topoisomerase I was stimulated by cAMP in a whole cell extract in a phosphorylation-dependent manner. These results suggest that topoisomerase I could be a target for nuclear events induced by peptide hormone action. |
| Databáze: | OpenAIRE |
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