High-sensitivity C-reactive protein predicts adverse outcomes after non-ST-segment elevation acute coronary syndrome regardless of GRACE risk score, but not after ST-segment elevation myocardial infarction
| Autor: | José Ramón González-Juanatey, Sergio Raposeiras Roubín, Pablo Aguiar Souto, Isabel Arufe, Michel Jacquet Hervet, Belén Outes, Ezequiel Álvarez Castro, José María García-Acuña, María V. Reino-Maceiras, Beatriz Paradela Dobarro, Filomena Roubín-Camiña, Maria José Castromán, Cristina Barreiro Pardal, Raymundo Ocaranza Sánchez, Emad Abu Assi |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Myocardial Infarction Risk Assessment Predictive Value of Tests Interquartile range Internal medicine medicine Humans ST segment Prospective Studies cardiovascular diseases Myocardial infarction Acute Coronary Syndrome General Environmental Science Aged Framingham Risk Score Ejection fraction business.industry Middle Aged Prognosis medicine.disease Surgery C-Reactive Protein lcsh:RC666-701 Coronary care unit Cardiology General Earth and Planetary Sciences Myocardial infarction complications Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Revista Portuguesa de Cardiologia, Vol 32, Iss 2, Pp 117-122 (2013) Revista Portuguesa de Cardiologia (English Edition), Vol 32, Iss 2, Pp 117-122 (2013) |
| ISSN: | 0870-2551 |
| Popis: | Introduction: Atherosclerosis is an active process and the inflammatory component appears to be particularly correlated with the development of acute coronary syndromes (ACS). C-reactive protein (CRP) is an acute phase protein that appears in the circulation in response to inflammatory cytokines. The present study investigated the association between high-sensitivity C-reactive protein (hsCRP) on admission and follow-up prognosis after an ACS. Methods: We included 151 consecutive patients admitted to the coronary care unit with a diagnosis of ACS (47% ST-segment elevation myocardial infarction [STEMI]). The primary endpoint was the combination of cardiac death and myocardial reinfarction during the follow-up period (median 19.8 months, interquartile range 16.3–23.7 months). Results: The occurrence of follow-up events was significantly related to admission hsCRP level, which was an excellent predictor of cardiac death and reinfarction during follow-up (HR 1.091, 95% CI 1.014–1.174; p=0.019). Stratifying the population based on type of ACS, adjusted by variables associated with cardiac events in univariate analysis (hsCRP, diabetes, depressed ejection fraction and GRACE risk score), hsCRP proved to be an independent predictor of follow-up outcomes only in non-STEMI patients (HR 1.217, 95% CI: 1.093–1.356, p |
| Databáze: | OpenAIRE |
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