Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy
| Autor: | Markus Kaski, Markku Partinen, Sakaewan Ounjaijean, Somdet Srichairatanakool, Tuomas Westermarck, Elżbieta Płonka-Półtorak, Faik Atroshi, Pekka Kaipainen, Suthat Fucharoen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Antioxidant Iron medicine.medical_treatment Pharmacology medicine.disease_cause Lipid peroxidation chemistry.chemical_compound medicine Humans Pharmacology (medical) chemistry.chemical_classification Valproic Acid Epilepsy medicine.diagnostic_test biology business.industry Transferrin saturation Ferritin Oxidative Stress chemistry Transferrin Serum iron biology.protein Anticonvulsants Female Lipid Peroxidation business Oxidative stress medicine.drug |
| Zdroj: | Int. Journal of Clinical Pharmacology and Therapeutics. 49:268-276 |
| ISSN: | 0946-1965 |
| Popis: | Objective This study aims to investigate the alteration of iron homeostasis and oxidative stress status in epilepsy patients treated with valproic acid (VPA) monotherapy. Materials 24 epilepsy patients receiving VPA monotherapy (12 men, 12 women, age 27.5 ± 7.2 y) and 24 sex- and age-matched healthy volunteers were included in the study. Methods The level of iron status parameters; serum iron, ferritin, transferrin saturation, non-transferrin bound iron (NTBI), serum level of trace elements (copper, zinc and selenium), concentration of antioxidant parameters, activities of antioxidant enzymes and level of lipid peroxidation product were determined. Results NTBI was found in the patients although their other iron status parameters were normal. Levels of antioxidant parameters were decreased while activities of antioxidant enzymes were increased. Levels of serum MDA were significantly increased in patients with epilepsy. The daily dose of valproic acid associated was statistically significant: serum concentration of NTBI (r = 0.579; p = 0.003) and MDA (r = 0.465; p = 0.022). A positive correlation existed between NTBI and zinc (r = 0.522; p = 0.009). Conclusion According to our results, VPA treatment in patients with epilepsy contributes to the metabolism of iron, leading to the formation of NTBI and an increase in oxidative stress. |
| Databáze: | OpenAIRE |
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