Combination therapy for treatment of osteoporosis: A review
| Autor: | Alan C. Dalkin, JoAnn V. Pinkerton |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Selective Estrogen Receptor Modulators medicine.medical_specialty Bone density Combination therapy Hormone Replacement Therapy medicine.medical_treatment Osteoporosis MEDLINE law.invention Anabolic Agents Randomized controlled trial law Teriparatide medicine Humans Intensive care medicine Bone Density Conservation Agents Diphosphonates business.industry Obstetrics and Gynecology Estrogens Bisphosphonate medicine.disease Sequential treatment Surgery Drug Therapy Combination Female Hormone therapy business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 197:559-565 |
| ISSN: | 0002-9378 |
| Popis: | Combination therapy for osteoporosis has been tested in small trials of short duration with various combinations. Pertinent human and animal randomized clinical trial data were identified through Medline and reviewed with a focus on the risks and benefits of different types of combination therapies. Improvements in bone density were found in some, but not all, combinations. There are no large trials of adequate length or numbers to determine fracture efficacy. Consider combination therapy if monotherapy is unsuccessful, if there is an added nonskeletal benefit to the proposed combination or as sequential treatment with an anabolic agent followed by an antiresorptive agent. Although combination therapy, in general, has limitations based on cost, concern about potential oversuppression of bone, and lack of long-term safety and fracture efficacy, selected patients may benefit. |
| Databáze: | OpenAIRE |
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