Perspectives into the possible effects of the B.1.1.7 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on spermatogenesis
| Autor: | Nihal Satyadev, Tess McClenahan, Andrea Mary Thomas Kallumadyil, Anand L Kulkarni, Samantha De Filippis, Robert S. Waters, Ananya Vungarala |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Infertility Male Physiology business.industry SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Type-II Pneumocytes Testicular pain COVID-19 General Medicine medicine.disease Virus Basigin Drug Discovery Immunology Medicine Humans medicine.symptom business Receptor Spermatogenesis |
| Zdroj: | Journal of basic and clinical physiology and pharmacologyReferences. 33(1) |
| ISSN: | 2191-0286 |
| Popis: | B.1.1.7 is a recently discovered variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with increased transmissibility. Recent findings indicate that this variant has a propensity to infect adolescents and children at higher rates than adults. The virus gains entry into various body cells utilizing angiotensin-converting enzyme 2 (ACE-2) and basigin (CD147) as receptors. The virus mainly affects type II pneumocytes of lungs, endothelial cells, enterocytes, and renal tubular cells. It is reported to affect testes, causing testicular pain, and producing histopathological changes, as observed in some autopsies. The B.1.1.7 variant can also affect various cells in the testes. This raises a major concern regarding the long-term effects of the viral infection on spermatogenesis and highlights the pressing need for a robust database of serum samples from infected male children. |
| Databáze: | OpenAIRE |
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