IL-6 gene amplification and expression in human glioblastomas
| Autor: | Pierre Verrelle, Jean-François Doré, Dubost Jj, Andrei Tchirkov, Christine Rolhion, Bertrand S |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
medicine.medical_treatment Polymerase Chain Reaction law.invention gene amplification and expression Downregulation and upregulation law Gene duplication Gene expression medicine Tumor Cells Cultured Humans Interleukin 6 Gene neoplasms Polymerase chain reaction DNA Primers IL-6 biology Interleukin-6 glioblastoma Gene Amplification Regular Article DNA Neoplasm nervous system diseases Gene Expression Regulation Neoplastic Real-time polymerase chain reaction Cytokine Oncology biology.protein Cancer research |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The aggressiveness of human gliomas appears to be correlated with the upregulation of interleukin 6 (IL-6) gene. Using quantitative PCR methods, we detected amplification and expression of the IL-6 gene in 5 of 5 primary glioblastoma samples and in 4 of 5 glioblastoma cell lines. This finding suggests that the amplification of IL-6 gene may be a common feature in glioblastomas and may contribute to the IL-6 over-expression. © 2001 Cancer Research Campaign http://www.bjcancer.com |
| Databáze: | OpenAIRE |
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