Systemic lupus erythematosus aggravates atherosclerosis by promoting IgG deposition and inflammatory cell imbalance

Autor:	T Liu, N Shi, S Zhang, G J Silverman, X-W Duan, H Niu
Rok vydání:	2020
Předmět:	Pathology medicine.medical_specialty hydroxychloroquine IgG Blood lipids 030204 cardiovascular system & hematology Coronary artery disease Mice 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Inflammatory cell Animals Lupus Erythematosus Systemic Medicine skin and connective tissue diseases 030203 arthritis & rheumatology Lupus erythematosus blood lipids business.industry Macrophages Hydroxychloroquine Dendritic Cells Atherosclerosis medicine.disease Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Immunoglobulin G Papers Systemic lupus erythematosus (SLE) Disease Progression Female business Deposition (chemistry) medicine.drug Artery
Zdroj:	Lupus
ISSN:	1477-0962 0961-2033
DOI:	10.1177/0961203320904779
Popis:	Background Systemic lupus erythematosus (SLE) patients experience a premature and more severe presentation of coronary artery disease. The underlying mechanisms of accelerated coronary artery disease in SLE patients remain to be elucidated. Methods By using atherosclerosis combining a SLE murine model, we proved that the onset of SLE aggravates atherosclerosis. Although the onset of SLE reduced blood lipids slightly, immune deviation contributed to aggravated atherosclerosis in lupus mice. Lupus atheroma were characterized by inflammatory cell infiltration, such as gathered dendritic cells, macrophages, and IgG deposition. Results Decreased lymphocytes and magnified dendritic cells in the spleen were also observed in lupus mice. Hydroxychloroquine prevented atherosclerosis progression mainly by reversing immune status abnormality caused by SLE. Serum interferon alfa levels were not changed in lupus mice. Conclusion These findings strongly suggested that anti-inflammatory therapies and hydroxychloroquine provide a new possible strategy for treating SLE patients with atherosclerosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c0a04d10caebd1a3da8c31b6cba02e https://doi.org/10.1177/0961203320904779 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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