Is Symptomatic Long QT Syndrome Associated with Depression in Women and Men?

Autor: Liisa Keltikangas-Järvinen, Mirka Hintsanen, Marko Elovainio, Heikki Swan, Mikael Koponen, Taina Hintsa, Ilmari Määttänen, Karolina Wesolowska, Annukka M. Tuiskula
Přispěvatelé: Medicum, University of Helsinki, Department of Psychology and Logopedics, Psychosocial factors and health, Doctoral Programme in Clinical Research, Clinicum, Kimmo Kontula Research Group, Department of Medicine, HUS Heart and Lung Center
Rok vydání: 2015
Předmět:
Male
Comorbidity
030204 cardiovascular system & hematology
Logistic regression
0302 clinical medicine
Mutation Carrier
FOUNDER MUTATIONS
Long QT syndrome (LQTS)
Medicine
030212 general & internal medicine
Registries
Young adult
Genetics (clinical)
Depression (differential diagnoses)
POPULATION
RISK
education.field_of_study
Depression
STRESSFUL LIFE EVENTS
1184 Genetics
developmental biology
physiology
Middle Aged
Long QT Syndrome
CORONARY-ARTERY-DISEASE
Female
medicine.symptom
Arrhythmia
Adult
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
SEX-DIFFERENCES
515 Psychology
Long QT syndrome
Population
Asymptomatic
03 medical and health sciences
Young Adult
Sex Factors
Internal medicine
Sex differences
Humans
cardiovascular diseases
education
Psychiatry
METAANALYSIS
Aged
business.industry
Long QTsyndrome (LQTS)
MAJOR DEPRESSION
medicine.disease
PHYSICAL-ACTIVITY
3121 General medicine
internal medicine and other clinical medicine
Mutation
GENDER
business
Zdroj: Journal of genetic counseling. 26(3)
ISSN: 1573-3599
Popis: We examined whether long QT syndrome (LQTS) mutation carrier status or symptomatic LQTS are associated with depression, and whether there are sex differences in these potential relationships. The sample comprised 782 participants (252 men). Of the 369 genetically defined LQTS mutation carriers, 169 were symptomatic and 200 were asymptomatic. The control group consisted of 413 unaffected relatives. Depression was assessed using the Beck Depression Inventory-II (BDI-II). No association was found for LQTS mutation carrier status with depression. The multinomial logistic regression showed that LQTS mutation carrier men with arrhythmic events scored higher on depression compared with the control group, even when adjusting for age, beta-blockers, antidepressants, and social support (OR = 1.09, 95 % CI [1.02, 1.15], p = .007). The binary logistic regression comparing symptomatic and asymptomatic LQTS mutation carriers showed that symptomatic LQTS was associated with depression in men (OR = 1.10, 95 % CI [1.03, 1.19], p = .009). The results were unchanged when additionally adjusted for education. These findings suggest that symptomatic LQTS is associated with depression in men but not in women. Overall, however, depression is more frequent in women than men. Thus, regular screening for depression in LQTS mutation carriers and their unaffected family members can be important.
Databáze: OpenAIRE
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